Genotype-phenotype connections From a genetics perspective, one of my main goals is to uncover the hidden genotype-phenotype links. Given that current assumptions are still quite rudimentary, biologically inspired new models (heterogeneity, regulatory networks, etc.) are very likely to be used to unveil new discoveries within vast existing datasets.
RNA & Protein kinetics Transcription initiates the process of translating genetic information into function. Despite the extensive coverage in molecular biology textbooks, our understanding of this process remains far from complete. My focus is on fundamental transcription processes, particularly those related to gene structure variations (such as alternative splicing, gene fusion, etc.), which are of great interest to me. Furthermore, I would like to study various post-transcriptional and post-translational modifications that profoundly affect functional outcome. These modifications tend to operate independently of genetic information and exhibit adaptive responses to environmental changes, ranging from the cellular to the individual level.
Systematic approaches in genetic enhancement We now have a remarkable opportunity to reconfigure the genetic code to drive breeding improvement, whether by enhancing existing phenotypes or by engineering entirely new traits. Integrating the knowledge gleaned from the above areas with additional systematic genomic strategies can greatly accelerate this process. This includes refining the predictability of gene editing, aiding in the optimization of gene editing tools, and using genome selection for precision breeding predictions.